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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK1
All Species:
19.39
Human Site:
S133
Identified Species:
32.82
UniProt:
Q13153
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13153
NP_001122092.1
545
60647
S133
D
V
L
E
F
Y
N
S
K
K
T
S
N
S
Q
Chimpanzee
Pan troglodytes
XP_508657
536
59744
S133
D
V
L
E
F
Y
N
S
K
K
T
S
N
S
Q
Rhesus Macaque
Macaca mulatta
XP_001090077
545
60664
S133
D
V
L
E
F
Y
N
S
K
K
T
S
N
S
Q
Dog
Lupus familis
XP_849651
544
60649
N132
L
D
V
L
E
F
Y
N
S
K
K
T
S
N
S
Cat
Felis silvestris
Mouse
Mus musculus
O88643
545
60718
S133
D
V
L
E
F
Y
N
S
K
K
T
S
N
S
K
Rat
Rattus norvegicus
P35465
544
60559
N132
L
D
V
L
E
F
Y
N
S
K
K
T
S
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509462
527
58159
A133
D
V
L
E
F
Y
N
A
K
K
A
S
N
S
Q
Chicken
Gallus gallus
NP_001155844
544
60631
N132
L
D
V
L
E
F
Y
N
S
K
K
T
S
S
S
Frog
Xenopus laevis
NP_001079232
564
62749
K151
K
E
T
V
N
N
Q
K
Y
M
S
F
T
S
G
Zebra Danio
Brachydanio rerio
NP_958485
577
63243
S132
D
V
L
K
F
Y
D
S
K
E
T
S
N
N
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
G231
N
L
A
P
P
S
G
G
S
M
P
Q
Q
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
Y158
Y
G
L
K
P
Q
P
Y
S
T
S
S
L
P
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
A483
A
P
K
P
P
S
S
A
S
A
S
A
P
I
I
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
Q537
D
N
V
Q
H
M
Y
Q
E
E
H
R
N
R
S
Conservation
Percent
Protein Identity:
100
94.3
99.6
96.6
N.A.
97.6
98.9
N.A.
78.7
94.5
80.6
81.9
N.A.
32.7
N.A.
54.7
N.A.
Protein Similarity:
100
95.2
99.6
97
N.A.
98.7
99
N.A.
85.3
96.8
88.3
87.8
N.A.
50.8
N.A.
68.7
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
93.3
6.6
N.A.
86.6
13.3
6.6
73.3
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
46.6
N.A.
100
46.6
N.A.
93.3
46.6
13.3
100
N.A.
20
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.5
32.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.6
43.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
0
15
0
8
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
50
22
0
0
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
36
22
0
0
0
8
15
0
0
0
0
0
% E
% Phe:
0
0
0
0
43
22
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
8
0
0
0
0
8
8
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% I
% Lys:
8
0
8
15
0
0
0
8
43
58
22
0
0
0
8
% K
% Leu:
22
8
50
22
0
0
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
15
0
0
0
0
0
% M
% Asn:
8
8
0
0
8
8
36
22
0
0
0
0
50
22
0
% N
% Pro:
0
8
0
15
22
0
8
0
0
0
8
0
8
8
0
% P
% Gln:
0
0
0
8
0
8
8
8
0
0
0
8
8
8
43
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
0
% R
% Ser:
0
0
0
0
0
15
8
36
43
0
22
50
22
50
29
% S
% Thr:
0
0
8
0
0
0
0
0
0
8
36
22
8
0
0
% T
% Val:
0
43
29
8
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
43
29
8
8
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _